Indications for use AnviMax:
Release form Anvimax:
powder for prigot. solution for oral administration [cranberry] 3, 12 pack.
powder for prigot. solution for oral administration [lemon] 3, 12 pack
powder for prigot. solution for oral administration [lemon with honey] 3, 12 pack
powder for prigot. solution for oral administration [raspberry] 3, 12 pack
powder for prigot. solution for oral administration [blackcurrant]3, 12 pack
tab. effervescent [with cranberry taste and aroma]: 10 pcs.
tab. effervescent [with raspberry flavor and aroma]: 10 pcs.
set of caps: 20 pcs.
Description Anvimax:
Effervescent tablets [with cranberry taste and aroma] from light pink to dark pink in color with lighter and darker blotches, round, flat-cylindrical, with a rough surface, beveled, with a characteristic odor; blotches of greenish-yellow color are allowed; hygroscopic.
1 tab.
paracetamol - 360 mg
vitamin C - 300 mg
calcium gluconate monohydrate- 100 mg
rimantadine hydrochloride - 50 mg
rutoside (trihydrate form) - 20 mg
loratadine 3 mg
Excipients : citric acid - 716 mg, sodium bicarbonate - 584 mg, sorbitol - 97.85 mg, macrogol (polyethylene glycol 6000) - 75 mg, isoleucine - 75 mg, cranberry flavor (food flavoring powder "Cranberry 924") - 75 mg, acesulfame potassium - 20 mg, aspartame - 20 mg, povidone (povidone K30) - 3.75 mg, red beetroot dye (E162) - 0.4 mg.
10 pieces. - polypropylene tubes (1) - cardboard packs.
Anvimax
R05X Other combination drugs Anvimax for colds
Clinical and pharmacological groups Anvimax:
A drug Anvimax for etiotropic and symptomatic therapy of respiratory viral infections
Active substance Anvimax:
vitamin C
paracetamol
loratadine
rutoside
rimantadine hydrochloride
calcium gluconate monohydrate
Pharmaco-therapeutic group Anvimax:
ARI and "cold" symptoms remedy
Storage conditions Anvimax
The powder should be stored out of the reach of children, in a dry, dark place at a temperature not exceeding 25 ° C.
Capsules should be stored out of the reach of children, protected from light at a temperature not exceeding 25 ° C.
Effervescent tablets should be stored out of the reach of children at temperatures above 25 ° C.
pharmachologic effect Anvimax:
The combined drug Anvimax has antiviral, interferonogenic, antipyretic, analgesic, antihistamine and angioprotective effects.
Paracetamol has analgesic and antipyretic effects.
Ascorbic acid is involved in the regulation of redox processes, contributes to normal capillary permeability, blood clotting, tissue regeneration, plays a positive role in the development of the body's immune responses, replenishes vitamin C deficiency.
Calcium gluconate , as a source of calcium ions, prevents the development of increased permeability and fragility of blood vessels that cause hemorrhagic processes in influenza and ARVI, has an anti-allergic effect (the mechanism is unclear).
Rimantadine has antiviral activity against the influenza A virus. By blocking the M 2 channels of the influenza A virus, it disrupts its ability to penetrate cells and release ribonucleoprotein, thereby inhibiting the most important stage of viral replication. Induces the production of interferons alpha and gamma. In influenza caused by the B virus, rimantadine has an antitoxic effect.
Rutoside is an angioprotective agent. Reduces capillary permeability, swelling and inflammation, strengthens the vascular wall. It inhibits aggregation and increases the degree of erythrocyte deformation.
Loratadine - a blocker of histamine H 1 receptors, prevents the development of tissue edema associated with the release of histamine.
Indications Anvimax:
etiotropic treatment of influenza type A;
symptomatic treatment of colds, flu and acute respiratory viral infections, accompanied by fever, chills, nasal congestion, sore throat, pain in the joints and muscles, headache.
Method of application, course and dosage
The drug is taken orally after meals.
The capsules should be taken with water.
The powder (contents of 1 sachet) must be dissolved in 1/2 cup (100 ml) of warm boiled water and stirred. The resulting solution should be consumed immediately after preparation.
The effervescent tablet must be dissolved in 1/2 cup of boiled warm water and stirred; the resulting solution should be consumed immediately after preparation.
Adults are prescribed 1 capsule P blue and 1 capsule P red (single dose) or 1 sachet of powder or 1 effervescent tab. 2-3 times / day The interval between doses of the drug is 4-6 hours.
The drug Anvimax should be taken within 3-5 days (no more than 5 days) until the symptoms of the disease disappear. If there is no improvement in the patient's well-being, the patient should stop using the drug and consult a doctor.
Overdose Anvimax:
Symptoms: during the first 24 hours after administration - pallor of the skin, nausea, diarrhea, vomiting, pain in the epigastric region; impaired glucose metabolism, metabolic acidosis, tachycardia, arrhythmia, headache, exacerbation of concomitant chronic diseases. Symptoms of liver dysfunction may appear 12-48 hours after an overdose. In case of severe overdose Anvimax - hepatic failure with progressive encephalopathy, coma; acute renal failure with tubular necrosis (including in the absence of severe liver damage).
The overdose threshold can be lowered in elderly patients, in patients taking certain drugs (for example, inducers of liver microsomal enzymes), alcohol, or malnutrition.
Treatment: the introduction of donors of SH-groups and precursors of the synthesis of glutathione-methionine within 8-9 hours after an overdose and acetylcysteine - within 8 hours. Gastric lavage, symptomatic therapy. The need for additional therapeutic measures (further administration of methionine, acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as on the time that has passed after its administration.
Drug interactions Anvimax:
Paracetamol reduces the effectiveness of uricosuric drugs Anvimax.
The concomitant use of paracetamol in high doses increases the effect of anticoagulant drugs.
Inducers of microsomal oxidation in the liver (phenytoin, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants), ethanol and hepatotoxic drugs increase the production of hydroxylated active metabolites, which makes it possible to develop severe intoxications even with a small overdose.
With simultaneous use with metoclopramide, it is possible to increase the rate of absorption of paracetamol.
Long-term use of barbiturates reduces the effectiveness of paracetamol.
Microsomal oxidation inhibitors reduce the risk of hepatotoxic effects.
Rimantadine enhances the aphrodisiac effect of caffeine.
Cimetidine reduces the clearance of rimantadine by 18%.
Ascorbic acid increases the concentration of benzylpenicillin in the blood.
Improves the absorption of iron preparations in the intestine (converts ferric iron to bivalent); can increase the excretion of iron while used with deferoxamine.
Increases the risk of crystalluria during treatment with short-acting salicylates and sulfonamides, slows down the excretion of acids by the kidneys, increases the excretion of drugs Anvimax with an alkaline reaction (including alkaloids).
Reduces the concentration in the blood of oral contraceptives.
Increases the total ethanol clearance, which in turn reduces the concentration of ascorbic acid in the body.
With simultaneous use, it reduces the chronotropic effect of isoprenaline.
Barbiturates and primidone increase the excretion of ascorbic acid in the urine.
Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) - phenothiazine derivatives.
Reduces tubular reabsorption of amphetamine and tricyclic antidepressants.
Loratadin
Inhibitors of CYP3A4 and CYP2D6 increase the concentration of loratadine in the blood.
Application during pregnancy and lactation Use during pregnancy and during breastfeeding is contraindicated.
Side effect Anvimax:
From the nervous system: increased excitability, drowsiness, tremors, hyperkinesia, dizziness, headache, "hot flashes" of blood to the face.
From the digestive system: damage to the mucous membrane of the stomach and duodenum, dyspepsia, dry mucous membrane in the mouth, lack of appetite, flatulence, diarrhea.
From the urinary system: moderate pollakiuria.
On the part of the hematopoietic system: changes in blood parameters (control is required).
Allergic reactions: angioedema, anaphylactic shock, skin rash, itching, urticaria.
Skin disorders : Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome), acute generalized exanthematous pustulosis.
Others: inhibition of the function of the insular apparatus of the pancreas (hyperglycemia, glucosuria).
Post -registration experience: during the use of Anvimax ® , cases of angioedema, light-headedness , fever, decreased blood pressure, urticaria, pruritus, erythema, hearing impairment, sore throat were described.
If any of the side effects indicated in the instructions are aggravated or any other side effects not indicated in the instructions are noted, the patient should immediately inform the doctor about it.
Contraindications for use Anvimax:
hypersensitivity to one or more of the components that make up the drug;
erosive and ulcerative lesions of the gastrointestinal tract in the acute phase;
gastrointestinal bleeding;
hemophilia;
hemorrhagic diathesis;
hypoprothrombinemia;
portal hypertension;
avitaminosis K;
renal failure;
thyroid disease;
acute diseases of the kidneys, liver (acute glomerulonephritis, acute pyelonephritis, acute hepatitis), or exacerbation of chronic diseases of these organs;
chronic alcoholism;
hypercalcemia, severe hypercalciuria;
nephrourolithiasis;
sarcoidosis;
simultaneous intake of cardiac glycosides (risk of arrhythmias);
lactose intolerance, lactase deficiency, glucose-galactose malabsorption (for capsules and powder);
intolerance to fructose (for effervescent tablets);
phenylketonuria (for powder and effervescent tablets);
pregnancy;
period of breastfeeding;
children under 18 years of age.
The drug should be used with caution and its use should be limited in case of epilepsy, cerebral atherosclerosis, diabetes mellitus, glucose-6-phosphate dehydrogenase deficiency, hemochromatosis, sideroblastic anemia, thalassemia, hyperoxaluria, urolithiasis, dehydration, electrolyte diaremia, syndrome malabsorption, calcium nephrourolithiasis (history), hypercalciuria; as well as in elderly patients with arterial hypertension (the risk of hemorrhagic stroke increases, due to the rimantadine, which is part of the drug).
Effervescent tablets should also be prescribed with caution while taking MAO inhibitors, tricyclic antidepressants simultaneously or previously within 2 weeks; concomitant use of drugs Anvimax that can adversely affect the liver (for example, inducers of liver microsomal enzymes); in the treatment of patients with recurrent formation of uric acid stones in the kidneys, with progressive malignant diseases, bronchial asthma.
special instructions Anvimax:
Duration of use - no more than 5 days.
The drug Anvimax should not be used in the presence of metastatic tumors.
Patients who abuse alcohol should consult a doctor before starting treatment with the drug, since paracetamol can have a damaging effect on the liver.
Influence on the ability to drive vehicles and mechanisms
During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.
Application for impaired renal function
The use of the drug Anvimax is contraindicated in renal failure, acute kidney disease (acute glomerulonephritis, acute pyelonephritis), or exacerbation of chronic kidney disease, nephrourolithiasis.
The drug Anvimax should be used with caution in case of calcium nephrourolithiasis (in history).
Application for violations of liver function Anvimax
The use of the drug Anvimax is contraindicated in portal hypertension, acute liver disease (acute hepatitis), or exacerbation of chronic liver disease.
