Betaderm ointment 15 mg

Betaderm ointment 15 mg

SKU:744
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Active substance:Betamethasone/Gentamicin
Pharmacological group:Antifungal
Formulation:Cream
Pills in 1 package:15
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Instructions for Betaderm

Description BETADERM:

A drug Betaderm with antibacterial and anti-inflammatory action for external use.

Composition Betaderm:

Betamethasone (in the form of betamethasone dipropionate) 0.5 mg.
Gentamicin (as gentamicin sulfate) 1 mg
Excipients.

Indications for use Betaderm:

  • Weeping inflammatory conditions of the skin (dermatoses), 
  • complicated by a secondary bacterial infection and occurring with hyperkeratosis, 
  • itching
  • atopic dermatitis
  • seborrheic dermatitis
  • simple chronic lichen
  • eczema
  • psoriasis
  • allergic contact dermatitis
  • systemic lupus erythematosus (skin manifestations)
  • polymorphic erythema

Pharmacokinetics Betaderm:

Betamethasone easily penetrates the skin through the stratum corneum. It does not undergo biotransformation in the skin and penetrates through it into the body. The absorption of betamethasone through the skin is increased when applied to delicate skin in the area of folds, when applied to skin with damaged epidermis or skin damaged by inflammation. In addition, absorption is increased with frequent use of the drug Betaderm or after application to a large skin surface. Betaderm
After topical application to intact skin, gentamicin is not absorbed, and after application to skin damaged by the pathological process, it can be absorbed into the bloodstream. Metabolism

Betamethasone is biotransformed mainly in the liver. Withdrawal
Betamethasone in the form of compounds with glucuronic acid and in small amounts in unchanged form is mainly excreted through the kidneys and, in smaller quantities, with bile.
Gentamicin is not biotransformed in the body and is excreted unchanged through the kidneys.

Pharmacodynamics Betaderm:

The properties of Betaderm are due to the combined action of betamethasone and gentamicin.
Betamethasone is a synthetic fluorinated hydrocortisone derivative that has a strong anti-inflammatory, antipruritic, anti-allergic and vasoconstrictor effect. Reduces inflammatory processes by inhibiting the production of prostaglandins and leukotrienes due to inhibition of the activity of phospholipase Ar and a decrease in the release of arachidonic acid from phospholipids of cell membranes, and also has an anti-allergic effect. 

Due to the local vasoconstrictor action, it reduces exudative reactions. Accelerates protein biotransformation in the skin and weakens proliferative processes. Gentamicin refers to antibiotics from the aminoglycoside group, is active against Streptococcus spp. (groups A - P-hemolytic and a-hemolytic), Staphylococcus spp. (Staphylococcus aureus - coagulase-positive and coagulase-negative and some strains that produce penicillinase), gram-negative bacteria: Escherichia coli, Proteus spp., Pseudomonas aeruginosa as well as bacteria from the Klebsiella spp., Enterobacter spp., Citrobacter spp., Citrabacter spp. and Shigella spp.

Contraindications Betaderm:

Viral and fungal skin infections
cutaneous manifestations of syphilis
lupus
rosacea and youthful acne
phlebitis and trophic ulcers
vaccination period and post-vaccination skin reactions
children under 2 years old
pregnancy

lactation period
hypersensitivity to drug Betaderm components.
The drug should be used with caution in case of atrophy of subcutaneous tissue in the elderly.

Side effects Betaderm:

Very rarely, when using Betaderm, there are: burning sensation, erythema, exudation, pigmentation disorders and itching.
May appear: acne, steroid purpura, inhibition of epidermal growth, atrophy of subcutaneous tissue, dry skin, depigmentation or hyperpigmentation of the skin, atrophy of the skin and striae, telangiectasia, folliculitis. Sometimes hives or maculopapular rash may appear.

With prolonged use or when applied to a large surface, systemic side effects characteristic of GCS are possible (suppression of the function of the adrenal cortex, increased body weight, osteoporosis, increased blood pressure, edema, ulceration of the gastrointestinal mucosa, exacerbation of hidden foci of infection, hyperkalemia, agitation, insomnia, violation of the menstrual cycle).

After application on the skin of the face, the drug can cause perioral dermatitis, and after application on the skin of the eyelids, it can sometimes cause an increase in the manifestations of glaucoma or the acceleration of the development of cataracts. In addition, given the presence of gentamicin content, symptoms of ototoxicity may appear if the drug Betaderm is applied to mucous membranes or a significant surface of the skin, especially damaged by a pathological process.
In children (side effects are additional to side effects in adults) - suppression of the hypothalamic-pituitary-adrenal system, Itsenko-Cushing's syndrome, growth retardation, lag in weight gain, increased ICP (betamethasone).

Method of preparation Betaderm:

Outwardly. Betaderm
Apply a small amount of the drug to the affected skin surface 1-2 times a day. Continuous use of the drug for a week should not exceed 45 g. The duration of treatment depends on the effectiveness and tolerability of therapy and is, as a rule, no more than 2-4 weeks.
Betaderm

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