Fenistil (Dimetindene) drops 20 ml

Fenistil (Dimetindene) drops 20 ml

SKU:1317
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Fenistil (Dimetindene) antihistamine, anti-allergic and antipruritic agent
Active substance:Dimetindene
Pharmacological group:Antiallergic agent
Formulation:drops
Dosage mg:0.001
In stock
$30
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Instructions for Fenistil (Dimetindene) drops 20 ml

Pharmacological properties:

Dimetindene maleate is a derivative of phenindene, is a histamine antagonist at the level of Н1 -receptors. It has an anti-kinin, weak anticholinergic and sedative effect. It has no anti-emetic effect. Reduces the increased permeability of capillaries associated with immediate allergic reactions.
In combination with histamine Н2 receptor antagonists, it inhibits almost all types of histamine action on the circulatory system.
The bioavailability of dimethindene in droplet form is about 70%. After ingestion, the maximum concentration in the blood plasma is reached for 2 hours. The half-life is about 6 hours.
At concentrations of 0.09 to 2 μg/ml, the binding of dimethindene to blood plasma proteins is about 90%.

Metabolic reactions include hydroxylation and methoxylation. Dimetindene and its metabolites are excreted with bile and urine. 5-10% of the accepted dose of the preparation is excreted with urine in an unchanged state.

Indications:

  • Symptomatic treatment of seasonal (hay fever) and year-round allergic rhinitis; 
  • cutaneous pruritus of various genesis except cholestasis-related;
  •  itching in diseases accompanied by skin rashes, in chickenpox, insect bites; 
  • drug Dimetindene and food allergies; 
  • urticaria as an adjuvant for eczema and other itchy dermatoses of allergic genesis; 
  • prevention of allergic reactions during desensitizing therapy.

Application:

Adults and children over 12 years of age and elderly patients
The daily dose is 3-6 mg in 3 doses: 20-40 Dimetindene drops 3 times a day. Patients prone to drowsiness are advised to prescribe 40 drops before bedtime and 20 drops in the morning during breakfast.

Children under 12 years of age
Taking the drug Dimetindene is recommended after preliminary consultation with a doctor. The daily dose is 0.1 mg/kg body weight. The table shows daily doses for children aged 1 month to 12 years and for adults. Application multiplicity - 3 times a day.

Age Single Dose/Dose Multiplicity
1 month - 1 year 3-10 drops/3 times a day
1-3 years 10-15 drops Fenistil/3 times a day
4-12 years old 15-20 drops/3 times a day

Adults 20-40 drops/3 times a day
20 drops = 1 ml = 1 mg of dimethindene maleate.

Phenistyl drops can be added to a bottle of warm baby food just before feeding. If the child is already fed from a spoon, drops can be given undisturbed teaspoon. The drops have a pleasant taste.

Contraindications:

Increased sensitivity to any component of the drug Dimetindene. Do not prescribe children under the age of 1 month, especially premature.

Side effects:

From the immune system: very rarely - anaphylactic reactions, including facial swelling, pharyngeal edema, skin rash, muscle spasms and shortness of breath.
From the GI: rarely - gastrointestinal disorders, nausea, dry mouth and throat.
From the CNS: often - drowsiness; rarely - arousal, headache, dizziness; very rarely - allergic reactions can occur.

Interactions:

When taken together, it is possible to mutual increase the sedation of Fenistil drops and CNS-suppressing drugs Fenistil, such as tranquilizers, sleeping pills and alcohol. With simultaneous alcohol consumption, a more pronounced slowdown in the rate of psychomotor reactions is possible.

When taken together with MAO inhibitors, it is possible to increase the anticholinergic activity of antihistamines, as well as increase their oppressive effect on the CNS; therefore, their combined use is not recommended. Tricyclic antidepressants and anticholinergics, when combined with antihistamines, may have additional anticholinergic effects.

Period of pregnancy and breastfeeding:

the gestation period of Fenistil drops can only be prescribed if the expected benefit to the mother exceeds the potential risk to the fetus. It is not recommended to take the drug Fenistil during breastfeeding, if necessary, treatment with the drug Fenistil Dimetindene should stop breastfeeding.

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Fenistil (Dimetindene) gel
SKU:1318
$28
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