Instructions for Neurobion (Cyanocobalamin, Pyridoxine, Thiamine)
pharmacodynamics:
The drug contains a combination of neurotropic active substances of vitamins B. Vitamins included in vitamins: thiamine (B1), pyridoxine (B6) and cyanokobomalamine (B12) play a special role as coenzymes in intermediate metabolism in the central nervous system and peripheral nervous system.
Like all other vitamins, they are essential nutrients that cannot be synthesized directly in the body.
Therapeutic administration of vitamins B1, B6 and B12 makes up for the insufficient intake of vitamins with food, which ensures the presence of the necessary amount of coenzymes in the body. The combined use of B vitamins increases their therapeutic effectiveness, as it is believed that the effectiveness of the combination exceeds the effectiveness of its individual components.
The therapeutic use of these vitamins in various diseases of the nervous system is aimed at, on the one hand, to compensate for both existing insufficiency (perhaps due to the increase in the body's need, caused directly by the disease) and on the other hand - to stimulate natural mechanisms of recovery. At the same time, the analgesic effect of the B vitamin complex has a beneficial effect on the therapeutic result.
pharmacokinetics:
Thiamine. After ingestion, its dosed transport is carried out, the mechanism of which has a dual nature: active absorption to concentration of 2 micromoles and passive diffusion at concentrations of 2 micromoles. The half-life of the human body can be up to 30 mg of thiamine. Given the rapid metabolism, reserves are very limited, they are consumed in 4-10 days.
Pyridoxine. Pyridoxin is absorbed very quickly, mainly in the upper part of the gastrointestinal tract, is excreted in a maximum of 2-5 hours.
There may be approximately 40-150 mg in the human body; 1.7-3.6 mg is excreted in urine per day.
Cyanocobalamin. Vitamin B12 is absorbed into the gastrointestinal tract by two mechanisms: release under the influence of gastric juice and rapid connection with the internal factor; regardless of the internal factor, due to passive ingestion into the bloodstream.
At doses of 1.5 micrograms, the latter mechanism plays a significant role.
In patients with pernicio anemia absorbed about 1% after taking doses of ≥100 micrograms. Vitamin B12 is mainly excreted with bile and is largely reabsorbed in intestinal and liver recycling.
Testimony:
As a supportive therapy of neurotic and neuralgia, such as:
trigeminal neuralgia;
Inter-bereath neuralgia;
Ishias;
lumbar syndrome (lumbago);
plexitis (neck and shoulder plexus);
Root neurotic neuritis due to degenerative diseases of the spine;
prosoplegia (defeat of the facial nerve).
application:
inwards
Adults and adolescents over the age of 15: 1 tablet 3 times a day. Tablets should be taken whole, washed down with liquid, after eating. The duration of the course is determined by the doctor individually in each case.
contraindications:
Hypersensitivity to the components of the drug.
Side effects:
Hypersensitivity reactions, mainly in the form of skin manifestations, very rarely occur after taking vitamin B1, as well as vitamin B12.
Special instructions:
With the introduction of vitamin B12 clinical picture, as well as laboratory indicators in funicular myelosis or perniciosionic anemia may lose its specificity.
Pregnancy and breast-feeding. To date, there is no data on undesirable effects in pregnancy after the introduction of vitamins B1, B6 and B12 in recommended doses.
Studies on the possible accumulation of these vitamins in breast milk above physiological norms were not conducted.
