Composition Nicergoline:
Dosage configuration: film-coated tablets Composition per tablet:
Active ingredient Nicergoline:
nicergoline (in terms of 100% substance) - 10.0 mg
Excipients: potato starch - 26.9 mg
colloidal silicon dioxide - 2.0 mg magnesium stearate - 1.1 mg lactose monohydrate - before purchasing a tablet in the absence of a shell with a set of 110.0 mg.
Coating auxiliary substances before purchasing a tablet with a coating of 180.0 mg: sugar (sucrose) - 48.1159 mg magnesium carbonate - 19.8800 mg povidone - 1.0000 mg, beeswax - 0.3880 mg, giant dioxide - 0, 3036 mg, talc - 0.2990 mg, colloidal silicon dioxide - 0.0135 mg.
Special circumstances Nicergoline:
In clinical studies, it was shown how, with a single or repeated use of nicergoline, a decrease in systolic and in the higher levels of diastolic arterial pressure can be noticed in patients with normal parameters and with increased arterial pressure. These fruits may vary, such as how the rest of the studies did not portray a change in the meanings of arterial pressure.
The drug influences gradually, therefore it must be met in the direction of a long pore, with this the doctor must periodically (at the extreme border of any 6 moons) request the effect of healing and the expediency of its continuation.
There has been a concern with the production of fibrosis (for example, pulmonary, poor fellow, heart valves and retroperitoneal) when using ergot alkaloids, which have antagonistic vigor in relation to 6HT2B serotonin receptors.
Signs of ergotism (including lightheadedness, vomiting, diarrhea, abdominal pain, and peripheral vasoconstriction) have been observed when enrolling individual ergot alkaloids and their derivatives.
It is appropriate for doctors to have a game of probable signs of ergot drug overdose prior to referral of a given class of drugs.
Impact on the ability to dispose of a car and second devices:
Despite how improves response and accumulation of interests, its effect on the ability to drive a car and use complex equipment has not been deliberately investigated. In each incident, care must be taken, taking into account the nature of the main illness, especially considering how dizziness or drowsiness can develop in certain incidents.
Drug interaction Nicergoline:
Nicergoline may increase the effect of antihypertensive drugs. Nicergoline is metabolized under the influence of the isoenzyme CYP2D6, therefore it is forbidden to release the potential of its interaction with drugs, any are metabolized with the sensitivity of this same enzyme.
When using nicergoline with acetylsalicylic acid, there may be an increase in bleeding pores.
Nicergoline affects the metabolism and excretion of uric acid, in relation to which, care must be taken when using it with drugs that affect the metabolism of uric acid.
Nicergoline potentiates the effect of beta-blockers on the heart, has an antagonistic effect on the vasoconstrictor effect of sympathomimetics through its alpha-adrenergic blocking effect.
Pharmacodynamics Nicergoline:
Nicergoline - an ergoline derivative, improves metabolic and hemodynamic processes in the brain, reduces platelet aggregation and improves hemorheological blood parameters, increases blood flow rate in the upper and lower limbs. Nicergoline exhibits an alpha-1-adrenergic blocking effect leading to improved blood flow and has a genuine effect on the cerebral neurotransmitter systems - noradrenergic, dopaminergic and acetylcholinergic. On the field of drug use, the energy of the noradrenergic, dopaminergic and acetylcholinergic cerebral systems increases, as it contributes to the optimization of cognitive processes. In the fruit of long-term nicergoline therapy, enduring improvements in cognitive function and a decrease in the severity of behavioral breakdowns associated with dementia have been observed.
Pharmokinetics Nicergoline:
Then enrolling inside, nicergoline is soon and almost completely absorbed. The main foodstuffs of nicergoline metabolism are 1,6-dimethyl-8p-hydroxymethyl-10a-metsxyergslin (MMDL, a hydrolysis product) and 6-methyl-8p-hydroxymethyl-10a-methoxyergoline (MDL, a product of dimethylation under the influence of the isoenzyme CYP2D6). The ratio of the meanings of the area under the one-eyed "concentration-time" (AUC) for MMDL and MDL when taking nicergoline internally indicates a pronounced metabolism "during the main passage" through the liver. Then the enrollment of 30 mg of nicergoline inside the largest accumulations of MMDL (21 ± 14 ng / ml) and MDL (41 ± 14 ng / ml) will be conquered after about 1 and 4 times according, then the accumulation of MDL decreases with a half-life of 13 - 20 hours. no accumulation of second metabolites (including MMDL) in the blood. Meal enrollment or drug configuration does not have a major effect on the level and rate of absorption of nicergoline. Nicergoline actively (> 90%) binds to plasma proteins, and the level of its similarity to a1-acid glycoprotein is predominantly than to serum albumin. It is depicted how nicergoline and its metabolites can
Testimonials
Symptomatic therapy of cognitive breakdowns, including dementia in chronic cerebrovascular and organic brain damage, accompanied by memory loss, accumulation of interests, thinking, energy, increased fatigue, and excitable disorders.
Note: before starting therapy with nicergoline, one must make sure that these signs are not detected by the manifestation of a second disease (how is it, spiritual diseases, psychiatric or neurological diseases) and do not cause characteristic therapy.
Contraindications Nicergoline:
Recent myocardial infarction, topical bleeding, severe bradycardia, disruption of orthostatic regulation, increased susceptibility to nicergoline, the second ergotamine derivatives or the second components of the drug, lack of sucrase / isomaltase, fructose intolerance, glucose-galactose malabsorption, pregnancy under 18 years of age feeding.
With care:
History of hyperuricemia or gout and / or in combination with medications, any disturbance of metabolism or excretion of uric acid.
Synchronous admission with agonists of sympathomimetics (alpha and beta).
Use during pregnancy and while breastfeeding:
Due to the lack of specific studies during pregnancy, nicergoline is contraindicated. At the time of enrollment of the drug, one must turn away from breastfeeding, for example, how nicergoline and its metabolic foods creep into the milk of abuse.
Studies in cattle have not noticed the effects of nicergoline on fertility.
Overdose Nicergoline:
Signs: a temporary pronounced lowering of the PRESENT. It is usually not necessary to have a special treatment, the patient only needs to drink a horizontal posture for a few times. In extraordinary incidents with a daring disruption of the blood supply to the brain and heart, the introduction of sympathomimetic drugs appears to be under constant control of arterial pressure.
Side effects Nicergoline:
System organ class Very dense> 1/10 Thick> 1/100 to <1/10 Rare> 1/1000 to <1/100 Exceptional> 1/10000 to <1/1000 Very exceptional <1 / 10,000 Density unfamiliar (cannot be requested due to the available data) *
Psychic breakdowns, psychomotor agitation, confusion of mind, insomnia
Breakdowns from the side of the nervous system drowsiness, dizziness, headache feeling of fever
Disruptions from the side of the vessels Decrease in arterial pressure (PRESENT), in the main sweat of parenteral administration, "flushes" of blood to the skin appearance
Disruptions from the side of the gastrointestinal tract a feeling of discomfort in the abdomen diarrhea, constipation, lightheadedness, dyspeptic symptoms
Tear off the side of the peel and subcutaneous skin rash
Laboratory and instrumental data - an increase in the accumulation of uric acid in the blood (this effect does not depend on the dose and duration of therapy)
Breakdowns from the side of the immune system, allergic reactions in the guise of skin irritation and rash
* Adverse reactions identified in the gait of post-registration nicergoline use.
There has been a concern with the production of fibrosis (for example, pulmonary, poor fellow, heart valves and retroperitoneal) when using ergot alkaloids, which have antagonistic vigor in relation to 6HT2B serotonin receptors.
Usage methods Nicergoline:
Inside.
The tablets should be met at the time of food, washed down with a low volume of liquid, without chewing.
The recommended daily dose collects 30-60 mg in bondage from the burden of symptoms and personal response to treatment in the patient.
The daily dose of 30 mg seems to be met at breakfast.
Painful with impaired renal function (serum creatinine> 2 mg / dL) nicergoline seems to be used in smaller therapeutic doses.
