Instructions for Remantadine (rimantadine)
English product name
Remantadin
Release form
tab. 50 mg: 10, or 20 pcs.
Description rimantadine
Tablets 1 tab.
rimantadine hydrochloride 50 mg
ATX codes
J05AC02 Rimantadine
Clinical and pharmacological groups / Group affiliation
Antiviral drug
Active substance
rimantadine hydrochloride
Pharmacotherapeutic group rimantadine
Antiviral agent
Pharmacological effect rimantadine
Rimantadine is a pharmacological agent, which is an adamantane derivative and has an antiviral effect. It actively affects various strains of influenza A, especially type A2. The unique polymer structure of rimantadine ensures its long-term circulation in the body, which allows it to be used for both therapeutic and prophylactic purposes. It inhibits the early stage of specific viral reproduction by reducing the RNA transcription after entry into the cell.
Acting as a weak base, rimantadine raises the pH of endosomes, the vacuum membranes surrounding viral particles inside the cell. Preventing acidification in these vacuoles blocks the fusion of the viral envelope with the endosome membrane, thereby preventing the transfer of viral genetic material into the cell cytoplasm. Also, rimantadine inhibits the release of virus particles from the cell, interrupting the transcription of the viral genome.
Indications for use rimantadine
rimantadine includes early treatment and prevention of influenza A in adults and children, depending on the form of the drug.
Method of use, course and dosage rimantadine
Dosing schedules are individualized based on patient indications, patient age, and formulation.
- Nosology (ICD codes)
- J10
- Influenza due to identified seasonal influenza virus
- Z29.8
- Other specified preventive measures
