Instructions for Trinalgin (Fenpiverinium bromide, Pitofenone, Metamizole)
English product name
Trinalgine
Pitofenone bromide
Release form
Solution for in/in and in/m introduction
Pitofenone bromide
Description:
Solution for in/in and in/m white injection, round, flat, with cut edges and a separating groove.
Pitofenone bromide
1 ml
sodium metamisole 500 mg
pitofenone hydrochloride 2 mg
Pitofenone bromide 0.02 mg
Auxiliary substances: sodium disulpite - 1 mg, sodium hydroxide solution 2M - sufficient quantity for bringing pH to 6.0-7.5, water d/i - to 1 ml.
Pitofenone bromide
ATC codes
N02BB52 Sodium methamisole in combination with other drugs (excluding psycholeptics)
Pitofenone bromide
Clinical-pharmacological groups / Group affiliation
Spasmoanalgetic
Pitofenone bromide
Active substance
sodium metamisole
Pitofenone bromide
Pharmacotherapy group
Testimony Fenpiverinium bromide:
- Pain syndrome (mild or moderate) in spasms of smooth muscles of internal organs: renal colic,
- urinary and bladder spasm;
- The Bile colic;
- biliary dyskinesia;
- post-cholecystectomy syndrome;
- bowel colic;
- chronic colitis;
- algodismenorrhea;
- pelvic diseases.
- For short-term treatment of arthralgia;
- myalgia;
- neuralgia,
- scialgia.
- As an auxiliary drug for pain syndrome after surgical interventions and diagnostic procedures.
How to take the drug:
Inside
Adults and adolescents over fifteen: one - two tabs. two - three times/day, without chewing, drinking a little liquid.
Children aged 12-14: a single dose is one taba., the maximum daily dose is six taba. (1.5 taba. 4 times/day), children aged 8-11 years - 0.5 taba., the maximum daily dose is four taba. (1 taba. 4 times/day), children aged 5-7 years - 0.5 taba., the maximum daily dose is two taba. (0.5 taba. 4 times/day).
Pharmacological effect:
Combined analgesic and spasmolytic agent. The combination of the components of the preparation leads to the mutual reinforcement of the pharmacological action thereof.
Sodium methamisole, a pyrazolone derivative, has analgesic, antipyretic and mild anti-inflammatory effects, the mechanism of which is associated with the suppression of prostaglandin synthesis.
Pitofenone hydrochloride has a direct myotropic effect on the smooth musculature of the internal organs and causes its relaxation (papaverine-like effect).
Fenpiverinium bromide has an m-cholinoblocking effect and has an additional myotropic effect on smooth musculature.
