Cavinton (Vinpocetine)

Cavinton (Vinpocetine)

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The drug, which improves cerebral circulation and cerebral metabolism, promotes accumulation in tissues. Cavinton has a vasodilating effect mainly on the vessels of the brain, improves blood supply and microcirculation in the tissues of the brain. Reduces platelet aggregation, Improves the tolerance of hypoxia by brain cells, facilitating the transport of oxygen to tissues.
Active substance:Vinpocetine
Pharmacological group:Nootropic
Country of origin:Hungary
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Scientific articles about the:

Pharmacological properties of Cavinton:

Vinpocetine has a complex mechanism of therapeutic action associated with a beneficial effect on blood circulation and brain metabolism, as well as on the rheological properties of blood. It has a neuroprotective (cerebroprotective) effect as follows: reduces the severity of damaging cytotoxic reactions caused by stimulating amino acids; inhibits the functional activity of both cellular transmembrane sodium and calcium tubules, and NMDA and AMPA receptors; potentiates the neuroprotective effect of adenosine; enhances the absorption and assimilation of glucose and oxygen by the brain; increases the resistance of neurons to hypoxia, stimulates the transport of glucose - a universal source of energy for the brain - through the BBB; translates glucose metabolism into an energetically more favorable aerobic direction;
selectively inhibits Ca2 + -calmodulin-dependent cGMP-phosphodiesterase, increases the concentration of cAMP and cGMP in brain tissues, as well as the concentration of ATP and the ratio of ATP / AMP; stimulates cerebral metabolism of norepinephrine and serotonin; stimulates the ascending noradrenergic system; has an antioxidant effect.

Cavinton (Vinpocetine) improves microcirculation in the brain tissue: inhibits platelet aggregation; reduces increased blood viscosity; increases the elasticity of red blood cells and inhibits the absorption of adenosine by them; promotes interstitial oxygen transport by reducing the affinity of red blood cells to it.

Selectively enhances cerebral blood flow through the following mechanisms: increases the cerebral fraction of the IOC; reduces the resistance of cerebral vessels without significantly affecting the parameters of systemic circulation, practically without affecting blood pressure, IOC, heart rate, TPVS; does not cause the phenomenon of "robbery" - on the contrary, when it is applied, the blood supply to the ischemic, but still viable part of the brain increases - the phenomenon of "reverse robbery".

Oral Vinpocetine bioavailability is 70%. The maximum concentration in blood plasma is noted 1 hour after administration. The half-life is 4.8 hours.

Indications of Cavinton: 

In neurology Vinpocetine: cerebral circulation insufficiency accompanied by neurological or mental disorders - transient ischemic attack, ischemic stroke, post-stroke condition, vascular dementia, atherosclerosis, post-traumatic and hypertensive encephalopathy, vertebrobasilar insufficiency.

In ophthalmology, vinpocetine: chronic vascular diseases of the choroid and retina (including angiospasm and thrombosis of the central artery or retinal vein).

In otiatrics: decreased hearing acuity of vascular, toxic (including drug) or other genesis (idiopathic, caused by noise overload), Meniere's disease, idiopathic tinnitus.

Application Cavinton: 

Inside Vinpocetine, 5-10 mg 3 times a day after meals.

Due to the absence of hepato- and nephrotoxic effects in Cavinton Forte, there is no need to adjust the dose of the drug in patients with kidney or liver diseases. If it is necessary to take the drug in a dose of 5 mg, the Cavinton Forte tablet is divided by risk in half.

Contraindications for Cavinton:
The period of pregnancy and lactation, hypersensitivity to vinpocetine or other components of the drug, acute phase of hemorrhagic stroke, severe coronary artery disease and arrhythmias.

Side effects Cavinton:

From the side of the cardiovascular system: with a frequency of 0.1% - depression of the ST segment and lengthening of the Q – T interval, tachycardia, extrasystole (the relationship of these disorders with the use of the drug is doubtful due to their spontaneous appearance), with a frequency of 0.8% - slight fluctuations in blood pressure (mainly in the direction of decrease), skin hyperemia, phlebitis.

From the side of the central nervous system (with a frequency of 0.9%): sleep disturbance (insomnia, drowsiness), dizziness, headache, weakness, excessive sweating (may be symptoms of the underlying disease).

From the digestive tract (with a frequency of 0.6%): dry mouth, nausea, heartburn.

Allergic reactions: in some cases - skin manifestations of allergies. Vinpocetine

Special instructions for Cavinton:

The experience of using Cavinton Forte in pediatric practice is insufficient.

In the presence of a syndrome of an extended Q – T interval or with the simultaneous use of drugs that provoke an extension of the Q – T interval, it is recommended to monitor the ECG.

In case of lactose intolerance, it should be borne in mind that each Cavinton Forte tablet (10 mg) contains 83 mg of lactose.

Interactions with the active ingredient vinpocetine: Cavinton Medication
Not marked.

Vinpocetine overdose:

Not described.

Storage conditions Cavinton:

In a dark place at a temperature of 15-30 ° C.

Cavinton (Vinpocetine)

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