Cortexin ® 10 vials

Composition Cortexin:

1 fl.
complex of water-soluble polypeptide fractions with a molecular weight of not more than 10,000 Da (cortexin) 10 mg
Excipients: glycine - 12 mg (stabilizer).
general description
Nootropic drug

Special conditions Cortexin:

Cortexin should be used only as directed by your doctor.
The dissolved drug vial should not be stored and used after storage. A solution of Cortexin® is not recommended to be mixed with other solutions.

There are no features of the action of the drug at the first dose or during its withdrawal.
In case of missing an injection, it is not recommended to administer a double dose, and carry out the next injection as usual on the intended day.
Special precautions for the destruction of unused drugs are not required.

Influence on the ability to drive vehicles and control mechanisms
The use of the drug does not affect the performance of potentially hazardous activities that require special attention and quick reactions (driving, working with moving mechanisms).

Overdose Cortexin:

Currently, cases of drug overdose have not been reported.
Drug interaction
The drug interaction of the drug Cortexin is not described.

Pharmacodynamics Cortexin:

It contains a complex of low molecular weight water-soluble polypeptide fractions with a molecular weight of not more than 10,000 Da isolated from livestock cerebral cortex. It penetrates through the BBB directly to nerve cells. The drug has a nootropic, neuroprotective, antioxidant and tissue-specific effect.
Nootropic effect
Improves higher brain functions, learning and memory processes, concentration, resistance to various stressful effects.

Neuroprotective effect
Protects neurons from damage by various endogenous neurotoxic factors (glutamate, calcium ions, free radicals), reduces the toxic effects of psychotropic substances.

Cortexin Antioxidant effect

It inhibits lipid peroxidation in neurons, increases the survival of neurons under conditions of oxidative stress and hypoxia.
Tissue-specific action
It activates the metabolism of neurons of the central and peripheral nervous system, reparative processes, improves the functions of the cerebral cortex and the general tone of the nervous system.
Mechanism of action
The mechanism of action of Cortexin is due to the activation of peptides of neurons and brain neurotrophic factors; optimization of the balance of metabolism of excitatory and inhibitory amino acids, dopamine, serotonin; GABA-ergic exposure; a decrease in the level of paroxysmal convulsive activity of the brain, the ability to improve its bioelectric activity; preventing the formation of free radicals (products of lipid peroxidation).

Pharmokinetics Cortexin:

The composition of Cortexin, the active substance of which is a complex of polypeptide fractions, does not allow the usual pharmacokinetic analysis of individual components.

Indications Cortexin:

As part of complex therapy of the following conditions and diseases:
- cerebrovascular accident and their consequences;
- traumatic brain injury and its consequences;
- encephalopathy of various origins;
- cognitive impairment (memory and thinking disorders);
- acute and chronic encephalitis and encephalomyelitis;
- epilepsy;
- asthenic conditions;
- suprasegmental autonomic disorders;
- reduced learning ability;
- Delay in psychomotor and speech development in children;
- critical conditions of newborns with perinatal injuries of the nervous system;
- various forms of cerebral palsy

Contraindications Cortexin:

- individual intolerance to the drug.
Pregnancy and lactation
The drug is contraindicated for use during pregnancy (due to lack of data from clinical studies).
If it is necessary to prescribe the drug during lactation, breast-feeding should be stopped (due to lack of clinical trial data).

Side effects Cortexin:

When using the drug according to indications, no side effect was detected. Theoretically, individual hypersensitivity to the components of the drug is possible.

Application methods Cortexin:

The Cortexin drug is administered in oil.

The contents of the vial before injection are dissolved in 1-2 ml of a 0.5% solution of procaine (novocaine), water for injection or 0.9% sodium chloride solution, directing the needle to the wall of the vial to avoid foaming, and administered once daily: for adults at a dose of 10 mg for 10 days; children with a body weight of up to 20 kg at a dose of 0.5 mg / kg, with a body weight of more than 20 kg - at a dose of 10 mg for 10 days. If necessary, repeat the course after 3-6 months.

In hemispheric ischemic stroke in the acute and early recovery periods, the drug is administered to adults at a dose of 10 mg 2 times / day (morning and afternoon) for 10 days, with a second course in 10 days.