indications for OTRIVIN Express (Oxymetazoline)
Release form OTRIVIN Express:
Nasal spray with menthol aroma.
Structure OTRIVIN Express:
Active ingredient: Oxymetazoline hydrochloride 0.5 mg;
Excipients OTRIVIN Express:
Sorbitol liquid, non-crystallizing (70%) 20.0 mg, sodium dihydrogen phosphate dihydrate 5.0 mg, hypromellose 5.0 mg, sodium chloride 4.5 mg, disodium edetate dihydrate
0.5 mg, benzalkonium chloride 50% solution 0 , 2 mg (in terms of benzalkonium chloride 0.1 mg), sodium hydrogen phosphate dodecahydrate 0.17 mg, purified water to 1.0 ml. Nasal spray with menthol aroma: Sorbitol 14.0 mg, sodium chloride 5.5 mg, macrogol glycerol hydroxystearate 2.5 mg, sodium dihydrogen phosphate dihydrate 2.0 mg, levomenthol (menthol) 0.3 mg, cineole (eucalyptol) 0.2 mg, disodium edetate dihydrate 0.5 mg, benzalkonium chloride 50% solution 0.2 mg (in terms of benzalkonium chloride 0.1 mg), sodium hydrogen phosphate dodecahydrate 0.1 mg, purified water to 1.0 ml.
Pharmaco-therapeutic group OTRIVIN Express:
The decongestant is an α-adrenergic agonist.
Pharmacological properties OTRIVIN Express:
Otrivin Express (oxymetazoline) is a sympathomimetic agent that acts on the α-adrenergic receptors of the nasal mucosa. It has a vasoconstrictor effect, reducing the swelling of the nasopharyngeal mucosa. When applied topically to the inflamed nasal mucosa, it reduces swelling and nasal discharge. Restores nasal breathing, eliminates edema of the nasal mucosa, helps to restore aeration of the paranasal sinuses, middle ear cavity, which reduces the likelihood of bacterial complications (sinusitis, sinusitis, otitis media). With local intranasal application in therapeutic concentrations, oxymetazoline does not have a systemic effect, does not irritate and does not cause hyperemia of the nasal mucosa. The drug OTRIVIN Express (Oxymetazoline) takes effect in 25 seconds,
OTRIVIN Express
Overdose OTRIVIN Express:
In case of oxymetazoline overdose, the clinical picture is characterized by: mydriasis, nausea, cyanosis, fever, tachycardia, drowsiness, decreased body temperature, bradycardia, shock-like hypotension, apnea and loss of consciousness.
Nonselective α-adrenergic antagonists, in particular phentolamine, can be used to lower blood pressure. In severe cases, intubation and mechanical ventilation may be required. In the case of a moderate or severe overdose as a result of accidental oral ingestion, activated charcoal and sodium sulfate (laxative) are prescribed, after a significant overdose, gastric lavage is prescribed. Conducting symptomatic therapy is shown. The use of vasopressors is contraindicated.
Indications for use OTRIVIN Express:
Symptomatic treatment of nasal congestion in acute respiratory diseases with symptoms of rhinitis (runny nose), acute allergic rhinitis, hay fever, sinusitis, eustachitis, otitis media (to reduce swelling of the nasopharyngeal mucosa). To facilitate the outflow of secretions in diseases of the paranasal sinuses. Preparing the patient for diagnostic manipulations in the nasal passages.
Mode of application OTRIVIN Express:
Intranasally.
Adults and children over 12 years old: 1 injection into each nasal passage 1-2 times a day. Should not be used more than twice a day.
Before first use, spray the nasal spray with several taps until the drug is evenly distributed.
1.Do not cut off the spray tip.
Clean your nose thoroughly.
Remove the protective cap. Hold the bottle vertically, supporting the bottom with your thumb, the tip between your middle and forefinger.
Direct the nozzle into the nasal passage by tilting the bottle forward slightly.
Press the nebulizing device while nebulizing the drug OTRIVIN Express and inhale through the nose at the same time.
Repeat for the other nasal passage.
After use, clean and dry the tip before closing it with the protective cap.
In the recommended dose, without consulting a doctor, use for no more than 7 days. Do not exceed the recommended dosage.
Oxymetazoline
Contraindications OTRIVIN Express:
Hypersensitivity to the drug components, transphenoidal hypophysectomy and surgical interventions on the membranes of the brain (in history), angle-closure glaucoma, pregnancy, atrophic rhinitis, age up to 12 years.
With care
Increased intraocular pressure, arterial hypertension, hyperthyroidism, diabetes mellitus, pheochromocytoma, porphyria, prostatic hyperplasia, diseases of the cardiovascular system. It is recommended to be careful when treating patients receiving MAO inhibitors at this time or have received them within the previous 2 weeks, tri- and tetracyclic antidepressants, as well as other drugs Oxymetazoline that increase blood pressure. If you have one of the listed diseases, be sure to consult your doctor before taking the drug OTRIVIN Express.
Side effects OTRIVIN Express:
Classification of the frequency of occurrence of adverse reactions: very often - more than 1/10 appointments (≥ 10%); often - more than 1/100, but less than 1/10 of appointments (≥ 1%, but ≤ 10%); infrequently - more than 1/1000, but less than 1/100 of appointments (≥ 0.1%, but ≤ 1%); rarely - more than 1/10000, but less than 1/1000 prescriptions (≥ 0.01%, but ≤ 0.1%); very rarely - less than 1/10000 appointments (≤ 0.01%). Nervous system disorders: Rarely: headache, insomnia, sedation, anxiety, irritability.
Very rare: anxiety, drowsiness.
From the gastrointestinal tract:
Rare: nausea.
Respiratory, chest and mediastinal disorders:
Often: nosebleeds, dryness of the nasal mucosa, discomfort from the nasal mucosa, sneezing. Uncommon: dry mouth, stomatitis, dry throat, sore throat. Cardiac disorders: Rarely: increased blood pressure, palpitations, tachycardia.
Skin and subcutaneous tissue disorders:
Rarely: exanthema, itching.
General disorders and disorders at the injection site:
Very rare: fatigue.
Allergic reactions:
Rarely: systemic allergic reactions (angioedema of the tongue, throat, lips and face). If any of the side effects indicated in the instructions are aggravated, or you notice any other side effects that are not indicated in the instructions, inform your doctor.
special instructions OTRIVIN Express:
Otrivin Express (Oxymetazoline) should not be used continuously for more than 7 days without consulting a doctor. Prolonged or excessive use of the drug can cause tachyphylaxis, "rebound" effect and atrophy of the nasal mucosa. Avoid getting the drug in the mouth, eyes or around the eyes. Eye contact may result in visual impairment. To avoid the spread of infection, it is necessary to use the drug Oxymetazoline individually.
