Instructions for Salbutamol aerosol for inhalation
English Product Name
Salbutamol-Pharmstandart
Release Form
Inhalation aerosol dosed
Description Salbutamol
Inhalation aerosol dosed in the form of a white or almost white suspension; sprayed as an aerosol cloud when exiting the cylinder.
1 dose
salbutamol sulfate 120 ug,
which corresponds to salbutamol content 100 ug
Auxiliary substances: ethanol (absolute ethyl alcohol) - 5.905 mg, oleic acid - 0.009 mg, R134a propellant (1,1,1,2-tetrafluoroethane) - 67.966 mg.
200 doses - aluminum cylinders (1) with dosing valve and spray nozzle - cardboard packs.
ATX codes
R03AC02 Salbutamol
Clinical and pharmacological groups / Group affiliation
Broncholytic drug - beta<SUB>2</SUB>-adrenomytic
Active ingredient
salbutamol (as sulfate)
Pharmacotherapeutic group Salbutamol
Bronchodilating agent - beta2-agonist selective
- Nosology (ICD codes)
- J42
- Chronic bronchitis, unspecified
- J43
- Emphysema
- J44
- Other chronic obstructive pulmonary disease
- J45
- Asthma
Pharmacological effect Salbutamol
Salbutamol is a beta-adrenomimetic drug with a primary effect on β2-adrenergic receptors. Within a therapeutic dose, it has bronchodilating effects on β2 adrenergic receptors of bronchial smooth muscle and rapidly (within 5 minutes) corrects 4 to 6 hours of reversible airway obstruction.
Salbutamol prevents and relieves bronchospasm, decreases airway resistance, and increases lung vital capacity. It also prevents the release of histamine, a slow-reacting substance from mast cells, and factors in neutrophil chemotaxis. It promotes mucociliary clearence (up to 36% in chronic bronchitis), stimulates mucus secretion, and activates the atrial fibrillation.
At recommended therapeutic doses, salbutamol does not adversely affect the cardiovascular system, does not cause high blood pressure. It has weak chronotropic and inotropic effects on myocardium compared to other drugs of this group, and promotes expansion of coronary arteries.
Salbutamol has metabolic properties that decrease plasma potassium, interfere with glycogenolysis and insulin production, cause hyperglycemic (especially in patients with asthma) and lipolitical effects, and increase the risk of acidosis.
Indications for use Salbutamol
Salbutamol is used to treat asthma symptoms when they occur, to prevent allergen- or exercise-related asthma-related spasms of bronchospasm, and as part of long-term asthma maintenance therapy. It is also effective for other chronic lung diseases that cause reversible airway obstruction, including chronic obstructive bronchitis and pulmonary emphysema.
Method of use, course and dosage
Salbutamol is inhaled and given by mouth. The dosage, method and scheme of use are determined individually depending on the indications, clinical situation, patient's age and the dosage form used.
